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Determining an optimal testing strategy for infants at risk for mother-to-child transmission of HIV-1 during the late postnatal period

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English: Web Page


Abstract only. In this study, children born to HIV-1-infected mothers enrolled in the HIV Prevention Trial Network trial 024 were tested for HIV-1 infection at six intervals within the first year of life. Mothers and infants received nevirapine prophylaxis. Estimations were made of the probability of being alive and having a positive test in each interval after 4-8 weeks and at 30 days after weaning, conditional on having acquired HIV during the late postnatal period. The interval with the highest probability was taken to be the optimal visit interval. The study found that testing at 1 month after weaning or 12 months of age (whichever comes first) identified 81% of those infected during the late postnatal period (after 4-8 weeks) through breastfeeding. In total, 93% (95% confidence interval 89, 98) of all infected infants would be detected if tests were performed at these two time points. In resource-limited settings, HIV-1 PCR testing at 4-8 weeks followed by a second test at 1 month after weaning or at 1 year of age (whichever comes first), led to the identification of the vast majority of HIV-1-infected infants.

Publisher: Lippincott Williams & Wilkins
Language: English
Format: Web Page
Regions: Global, Sub-Saharan Africa
Audiences: Doctors/Physicians, Policymakers, Program Managers
Topic Area: Testing & Counseling
Resource Type: Journal Articles