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Antiretroviral Agents and Prevention of Malaria in HIV-Infected Ugandan Children

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English: Web Page


The authors compared malaria incidence in HIV-infected children on protease inhibitor-based regimens (lopinavir–ritonavir) to those receiving nonnucleoside reverse-transcriptase inhibitor (NNRTI)–based ART. They conclude that lopinavir–ritonavir–based ART as compared with NNRTI-based ART reduced the incidence of malaria by 41 per cent, with the lower incidence attributable largely to a significant reduction in the recurrence of malaria after treatment with artemether–lumefantrine. Lopinavir–ritonavir–based ART was accompanied by an increase in serious adverse events.

Publisher: Massachusetts Medical Society
Language: English
Format: Web Page
Region: Global
Audiences: Policymakers, Program Managers, Researchers
Topic Areas: Opportunistic Infections & Associated Conditions, Primary Care of HIV Infected & Exposed Children, Pediatric Antiretroviral Treatment
Resource Type: Journal Articles